PER2 anticorps (AA 13-330) (Fluoro550)

N° du produit ABIN8020497

L’anticorps anti-PER2 Polyclonal Lapin est utilisé pour la détection de PER2 dans des échantillons de Humain. Il a été validé pour FACS.

Aperçu rapide pour PER2 anticorps (AA 13-330) (Fluoro550) (ABIN8020497)

Antigène: PER2 (Period Circadian Protein 2 (PER2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PER2 est conjugé à/à la Fluoro550

Application: Flow Cytometry (FACS)

Détail du produit anti-PER2 anticorps (Fluoro550)

Épitope: AA 13-330

Fonction: Anti-PER2 Antibody Fluoro550 Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: Human PER2 shares 84%,83% amino acid (aa) sequence identity with mouse,rat PER2,respectively.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human PER2 recombinant protein (Position: N13-K330). Human PER2 shares 84% and 83% amino acid (aa) sequence identity with mouse and rat PER2, respectively.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur PER2

Antigène: PER2 (Period Circadian Protein 2 (PER2))

Autre désignation: PER2

Sujet:

Background: The PER2 gene encodes the period circadian protein homolog 2 protein in humans. This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. PER2 is mapped to 2q37.3. It has been showed that PER2 can positively stimulate activity of the Bmal1-Npas2 transcription complex and, in turn, Npas2 transcriptionally regulates delta-aminolevulinate synthase. PER2 is involved in a negative-feedback loop that attenuates estrogen stimulation and links the circadian cycle to estrogen receptor signaling. The rhythmic levels of PER2 are critical for circadian oscillations in cells and intact organisms. What's more, the PER2 gene also functions in tumor suppression by regulating DNA damage-responsive pathways.

Gene Full Name: period circadian regulator 2

Sequence Similarities: Contains 1 PAC (PAS-associated C-terminal) domain.

ID gène: 8864

UniProt: O15055