PI4KB anticorps (AA 375-671) (Fluoro647)

N° du produit ABIN8021264

Cet anticorps Lapin Polyclonal détecte spécifiquement PI4KB dans FACS. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour PI4KB anticorps (AA 375-671) (Fluoro647) (ABIN8021264)

Antigène: PI4KB (Phosphatidylinositol 4-Kinase, Catalytic, beta (PI4KB))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PI4KB est conjugé à/à la Fluoro647

Application: Flow Cytometry (FACS)

Détail du produit anti-PI4KB anticorps (Fluoro647)

Épitope: AA 375-671

Fonction: Anti-PI4KB Antibody Fluoro647 Conjugated

Réactivité croisée (Details): No cross reactivity with other proteins.

Homologie: Human PI4KB shares 100%,99.7% amino acid (aa) sequence identity with mouse,rat PI4KB,respectively

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human PI4KB recombinant protein (Position: D375-D671). Human PI4KB shares 100% and 99.7% amino acid (aa) sequence identity with mouse and rat PI4KB, respectively

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur PI4KB

Antigène: PI4KB (Phosphatidylinositol 4-Kinase, Catalytic, beta (PI4KB))

Autre désignation: PI4KB

Sujet:

Background: Phosphatidylinositol 4-kinase beta is an enzyme that in humans is encoded by the PI4KB gene. Inositol phospholipids have an important role in intracellular signaling in response to hormones, growth factors and neurotransmitters. Phosphatidylinositol 4-kinase phosphorylates phosphatidylinositol (PI) to phosphatidylinositol-4-phosphate (PIP). In a second step, PIP is further phosphorylated to phosphatidylinositol-4,5-bisphosphate (PIP2), and PIP2 is subsequently hydrolyzed by phospholipase C, producing the two intracellular second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PI4K230, PI4K92 and PI4K55 are three PI4 kinase isoforms that have been characterized and classified according to their molecular weights of 230, 92 and 55 kD. Previously, PI4 kinases were classified into type II and III enzymes. All isoforms are located on distinct membranes and cellular compartments suggesting various tasks. PI4K230 is located at the endoplasmatic reticulum and outer membranes of mitochondria, PI4K92 at the Golgi apparatus and endoplasmatic reticulum, and PI4K55 at the plasma membrane and endosomes. PI4K230 is predominantly expressed in brain and moderately sensitive to wortmannin as well as specifically and irreversibly inhibited by cyclitol derivatives.

Gene Full Name: phosphatidylinositol 4-kinase beta

ID gène: 5298

UniProt: Q9UBF8

Pathways: Inositol Metabolic Process