IRGM anticorps (AA 51-150) (Cy3)

N° du produit ABIN752566

Cet anticorps Lapin Polyclonal détecte spécifiquement IRGM dans WB, IF (cc) et IF (p). Il présente une réactivité envers Humain.

Aperçu rapide pour IRGM anticorps (AA 51-150) (Cy3) (ABIN752566)

Antigène: IRGM (Immunity-Related GTPase Family, M (IRGM))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IRGM est conjugé à/à la Cy3

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-IRGM anticorps (Cy3)

Épitope: AA 51-150

Homologie: Human,Mouse,Rat,Dog

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human IRGM

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur IRGM

Antigène: IRGM (Immunity-Related GTPase Family, M (IRGM))

Autre désignation: IRGM

Sujet:

Synonyms: Irgm, I1, Iigp3, Immunity related GTPase family M protein 1, Immunity related GTPase family, M, Interferon inducible protein 1, IRGM1, LRG 47, LRG47, IRGM_HUMAN.

Background: IRGM belongs to a family of interferon-gamma inducible GTPases, belonging to the GTPase superfamily, and are selectively induced by IFN-gamma or bacterial lipopolysaccharide (LPS) stimulation. IRGM is primarily expressed in all cells derived from B-cell lineages, and is highly expressed in macrophages following IFN-gamma stimulation. IRGM has been shown to be required for host defences against a broad range of intracellular pathogens. Specifically, IRGM deficient mice show defects with intracellular microbial killing, phagosome maturation and autophagy. More recently IRGM has been shown to inhibit baseline hematopoietic proliferation and is required for a normal hematopoietic stem cell response to chemical and infectious stimuli.

ID gène: 345611