Podoplanin anticorps (C-Term) (Fluoro594)

N° du produit ABIN8023572

L’anticorps anti-Podoplanin Polyclonal Lapin est utilisé pour la détection de Podoplanin dans des échantillons de Souris et Rat. Il a été validé pour FACS.

Aperçu rapide pour Podoplanin anticorps (C-Term) (Fluoro594) (ABIN8023572)

Antigène: Podoplanin (PDPN)

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Podoplanin est conjugé à/à la Fluoro594

Application: Flow Cytometry (FACS)

Détail du produit anti-Podoplanin anticorps (Fluoro594)

Épitope: C-Term

Fonction: Anti-Podoplanin/gp36/PDPN Antibody Fluoro594 Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: different from the related mouse sequence by one amino acid.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of rat Podoplanin/gp36, different from the related mouse sequence by one amino acid.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur Podoplanin

Antigène: Podoplanin (PDPN)

Autre désignation: PDPN

Sujet:

Background: PDPN (Podoplanin), also called T1A, T1A2, GP36, OTS8 or AGGRUS, is a protein that in humans is encoded by the PDPN gene. This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The PDPN gene is mapped to chromosome 1 by the International radiation Hybrid mapping consortium. The physiological function of PDPN may be related to its mucin-type character. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Immunohistochemical analysis of PDPN in placenta, kidney, lung, and nasal polyps showed expression at the apical plasma membrane of vascular endothelial cells and in alveolar epithelial cells. Overexpression of rat PDPN in human and rodent endothelial cells promoted formation of elongated cell extensions and significantly increased endothelial cell adhesion, migration, and tube formation. Inhibition of PDPN expression by small interfering RNAs decreased cell adhesion in cultured human dermal lymphatic endothelial cells.

Gene Full Name: podoplanin

Sequence Similarities: Belongs to the heparin-binding growth factors family.

ID gène: 54320

UniProt: Q64294

Pathways: Dicarboxylic Acid Transport