PAPPA anticorps (AA 95-388) (Biotin)

N° du produit ABIN8025106

Cet anticorps anti-PAPPA Polyclonal Lapin conjugué à Biotin (ABIN8025106) détecte spécifiquement PAPPA dans IHC, WB et ELISA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour PAPPA anticorps (AA 95-388) (Biotin) (ABIN8025106)

Antigène: PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PAPPA est conjugé à/à la Biotin

Application: Immunohistochemistry (IHC), Western Blotting (WB), ELISA

Détail du produit anti-PAPPA anticorps (Biotin)

Épitope: AA 95-388

Fonction: Anti-PAPP A/PAPPA Antibody Biotin Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: Human PAPP A shares 88% amino acid (aa) sequence identity with mouse PAPP A.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human PAPP A recombinant protein (Position: R95-Q388). Human PAPP A shares 88% amino acid (aa) sequence identity with mouse PAPP A.

Isotype: IgG

Information d'application

Indications d'application: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur PAPPA

Antigène: PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))

Autre désignation: PAPPA

Sujet:

Background: Pappalysin-1, also known as DIPLA1, is a protein that in humans is encoded by the PAPPA gene. It is mapped to 9q33.1. PAPPA is found in the ovarian follicles, follicular fluid, luteal cells, and fallopian tubes of nonpregnant women and in the seminal vesicles and seminal fluid of males. This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. It has been found that circulating PAPPA is a disulfide-bridged complex with proMBP in which the subunits of the constituents are present in a 1:1 Molar ratio.

Gene Full Name: pappalysin 1

Sequence Similarities: Belongs to the peptidase M43B family.

ID gène: 5069

UniProt: Q13219