PSTPIP1 anticorps (AA 1-394) (Cy3)

N° du produit ABIN8025951

L’anticorps anti-PSTPIP1 Polyclonal Lapin est utilisé pour la détection de PSTPIP1 dans des échantillons de Humain. Il a été validé pour FACS.

Aperçu rapide pour PSTPIP1 anticorps (AA 1-394) (Cy3) (ABIN8025951)

Antigène: PSTPIP1 (Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PSTPIP1 est conjugé à/à la Cy3

Application: Flow Cytometry (FACS)

Détail du produit anti-PSTPIP1 anticorps (Cy3)

Épitope: AA 1-394

Fonction: Anti-PSTPIP1 Antibody Cy3 Conjugated

Homologie: Human PSTPIP1 shares 87.3% amino acid (aa) sequence identity with mouse PSTPIP1.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human PSTPIP1 recombinant protein (Position: M1-D394). Human PSTPIP1 shares 87.3% amino acid (aa) sequence identity with mouse PSTPIP1.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur PSTPIP1

Antigène: PSTPIP1 (Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1))

Autre désignation: PSTPIP1

Sujet:

Background: Proline-serine-threonine phosphatase-interacting protein 1 is an enzyme that in humans is encoded by the PSTPIP1 gene. This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organization and inflammatory processes. It binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, downregulating CD2-triggered adhesion. It binds PEST-type protein tyrosine phosphatases (PTP) and s them to c-Abl kinase to mediate c-Abl dephosphorylation, thereby, regulating c-Abl activity. It also interacts with pyrin, which is found in association with the cytoskeleton in myeloid/monocytic cells and modulates immunoregulatory functions. Mutations in this gene are associated with PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. It is hypothesized that the disease-causing mutations compromise physiologic signaling necessary for the maintenance of a proper inflammatory response.

Gene Full Name: proline-serine-threonine phosphatase interacting protein 1

ID gène: 9051

UniProt: O43586