G6PC anticorps

N° du produit ABIN752998

Cet anticorps Lapin Polyclonal détecte spécifiquement G6PC dans WB, IF (p) et IHC (p). Il présente une réactivité envers Humain, Souris, Rat, Chien, Boeuf (Vache) et Porc et a été mentionné dans 1 publication.

Aperçu rapide pour G6PC anticorps (ABIN752998)

Antigène: G6PC (Glucose 6-Phosphatase, Catalytic (G6PC))

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp G6PC est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-G6PC anticorps

Réactivité croisée: Boeuf (Vache), Chien, Humain, Souris, Porc, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Glucose 6 phosphatase alpha

Isotype: IgG

Information d'application

Indications d'application: WB(1:100-500)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Références pour anticorps anti-G6PC (ABIN752998)

Yao, Zhuang, Du, Cheng, Yang, Guan, Hu, Zhu, Christine, Shi, Hua: "Role of Fas-associated death domain-containing protein (FADD) phosphorylation in regulating glucose homeostasis: from proteomic discovery to physiological validation." dans: Molecular & cellular proteomics : MCP, Vol. 12, Issue 10, pp. 2689-700, (2013) (PubMed).

Détails sur G6PC

Antigène: G6PC (Glucose 6-Phosphatase, Catalytic (G6PC))

Autre désignation: Glucose 6 phosphatase alpha

Sujet:

Synonyms: glucose-6-phosphatase, catalytic subunit, GSD1, AW107337, G-6-Pase, G6Pase, G6Pase-alpha, g6pc, G6PC_HUMAN, G6PT, Glucose-6-phosphatase alpha, Glucose-6-phosphatase, GSD1a, MGC163350, MGC93613, RP23-281C18.19.

Background: Glucose-6-phosphatase (G6Pase), is a multicomponent enzyme system that hydrolyzes glucose-6-phosphate (G6P) in the final step of gluconeogenesis and gluconeolysis. G6Pase localizes to the endoplasmic reticulum, and while liver, kidney, and intestine are the only tissues that express the first identified isoform, G6Pase-i±, a second form, designated G6Pase-i², contributes to blood glucose homeostasis in a wider range of tissues. G6Pase-i², also known as SCN4, UGRP or G6PC3 (glucose 6 phosphatase, catalytic, 3), is a 346 amino acid endoplasmic reticulum multi-pass membrane protein that is involved in carbohydrate biosynthesis and the gluconeogenesis pathway. Inhibited by vanadate, G6Pase-i² hydrolyzes GP6 to glucose in the endoplasmic reticulum. Due to its necessary involvement in normal glucose metabolism, G6Pase-i² may play an integral role in diabetes and glycogen storage diseases (GSDs).

Poids moléculaire: 40kDa

ID gène: 2538

Pathways: Carbohydrate Homeostasis, Cellular Glucan Metabolic Process