RAD17 anticorps (AA 1-267) (Fluoro594)

N° du produit ABIN8030055

L’anticorps anti-RAD17 Polyclonal Lapin est utilisé pour la détection de RAD17 dans des échantillons de Souris et Rat. Il a été validé pour FACS.

Aperçu rapide pour RAD17 anticorps (AA 1-267) (Fluoro594) (ABIN8030055)

Antigène: RAD17

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAD17 est conjugé à/à la Fluoro594

Application: Flow Cytometry (FACS)

Détail du produit anti-RAD17 anticorps (Fluoro594)

Épitope: AA 1-267

Fonction: Anti-Rad17 Antibody Fluoro594 Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived mouse Rad17 recombinant protein (Position: M1-Q267).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur RAD17

Antigène: RAD17

Autre désignation: Rad17

Sujet:

Background: The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified.

Gene Full Name: RAD17 checkpoint clamp loader component

ID gène: 19356

UniProt: Q6NXW6