RAG2 anticorps (AA 46-503) (Fluoro550)

N° du produit ABIN8031005

Cet anticorps Lapin Polyclonal détecte spécifiquement RAG2 dans FACS. Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour RAG2 anticorps (AA 46-503) (Fluoro550) (ABIN8031005)

Antigène: RAG2 (Recombination Activating Gene 2 (RAG2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAG2 est conjugé à/à la Fluoro550

Application: Flow Cytometry (FACS)

Détail du produit anti-RAG2 anticorps (Fluoro550)

Épitope: AA 46-503

Fonction: Anti-RAG2 Antibody Fluoro550 Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human RAG2 recombinant protein (Position: F46-K503).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur RAG2

Antigène: RAG2 (Recombination Activating Gene 2 (RAG2))

Autre désignation: RAG2

Sujet:

Background: Recombination activating gene 2, also known as RAG-2, is a protein that in humans is encoded by the RAG2 gene. This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.

Gene Full Name: recombination activating 2

ID gène: 5897

UniProt: P55895

Pathways: Chromatin Binding, Production of Molecular Mediator of Immune Response