RGMB anticorps (AA 47-404) (APC)

N° du produit ABIN8032080

L’anticorps anti-RGMB Polyclonal Lapin est utilisé pour la détection de RGMB dans des échantillons de Humain et Souris. Il a été validé pour FACS.

Aperçu rapide pour RGMB anticorps (AA 47-404) (APC) (ABIN8032080)

Antigène: RGMB (RGM Domain Family, Member B (RGMB))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RGMB est conjugé à/à la APC

Application: Flow Cytometry (FACS)

Détail du produit anti-RGMB anticorps (APC)

Épitope: AA 47-404

Fonction: Anti-DRAGON/RGMB Antibody APC Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human DRAGON/RGMB recombinant protein (Position: D47-R404).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur RGMB

Antigène: RGMB (RGM Domain Family, Member B (RGMB))

Autre désignation: RGMB

Sujet:

Background: Repulsive guidance molecule B (RGMb), also known as DRAGON (DRG11-responsive axonal guidance and outgrowth of neurite), is a bone morphogenetic protein (BMP) co-receptor of the repulsive guidance molecule family. In humans this protein is encoded by the RGMB gene. RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see also RGMA and RGMC) and contributes to the patterning of the developing nervous system. There is a potential association between RGMs and cancer bone metastasis, as RGMs coordinate bone morphogenetic protein (BMP) signaling. RGMB may act as a negative regulator in vitro in breast cancer and prostate cancer through BMP signalling. Furthermore, aberrant expression of RGMs was indicated in breast cancer. The perturbed expression was associated with disease progression and poor prognosis.

Gene Full Name: repulsive guidance molecule BMP co-receptor b

ID gène: 285704

UniProt: Q6NW40