RGMB anticorps (AA 47-404)

N° du produit ABIN8032083

L’anticorps anti-RGMB Polyclonal Lapin est utilisé pour la détection de RGMB dans des échantillons de Humain et Souris. Il a été validé pour WB, ELISA et FACS.

Aperçu rapide pour RGMB anticorps (AA 47-404) (ABIN8032083)

Antigène: RGMB (RGM Domain Family, Member B (RGMB))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RGMB est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Classe de qualité: Carrier-free

Détail du produit anti-RGMB anticorps

Épitope: AA 47-404

Fonction: Anti-DRAGON/RGMB Antibody

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-DRAGON/RGMB Antibody. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human DRAGON/RGMB recombinant protein (Position: D47-R404).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human, Mouse Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur RGMB

Antigène: RGMB (RGM Domain Family, Member B (RGMB))

Autre désignation: RGMB

Sujet:

Background: Repulsive guidance molecule B (RGMb), also known as DRAGON (DRG11-responsive axonal guidance and outgrowth of neurite), is a bone morphogenetic protein (BMP) co-receptor of the repulsive guidance molecule family. In humans this protein is encoded by the RGMB gene. RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see also RGMA and RGMC) and contributes to the patterning of the developing nervous system. There is a potential association between RGMs and cancer bone metastasis, as RGMs coordinate bone morphogenetic protein (BMP) signaling. RGMB may act as a negative regulator in vitro in breast cancer and prostate cancer through BMP signalling. Furthermore, aberrant expression of RGMs was indicated in breast cancer. The perturbed expression was associated with disease progression and poor prognosis.

Gene Full Name: repulsive guidance molecule BMP co-receptor b

Poids moléculaire: 48 kDa

ID gène: 285704

UniProt: Q6NW40