SH2D1A anticorps (Middle Region)

N° du produit ABIN8036866

Cet anticorps anti-SH2D1A Polyclonal Lapin (ABIN8036866) détecte spécifiquement SH2D1A dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour SH2D1A anticorps (Middle Region) (ABIN8036866)

Antigène: SH2D1A (SH2 Domain Containing 1A (SH2D1A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SH2D1A est non-conjugé

Application: Western Blotting (WB)

Classe de qualité: Carrier-free

Détail du produit anti-SH2D1A anticorps

Épitope: Middle Region

Fonction: Anti-SH2D1A Antibody

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-SH2D1A Antibody. Tested in WB applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence in the middle region of human SH2D1A.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for six months. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur SH2D1A

Antigène: SH2D1A (SH2 Domain Containing 1A (SH2D1A))

Autre désignation: SH2D1A

Sujet:

Background: This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Full Name: SH2 domain containing 1A

Poids moléculaire: 16 kDa

ID gène: 4068

UniProt: O60880

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process