CD43 anticorps (AA 272-400) (APC)

N° du produit ABIN8037216

L’anticorps anti-CD43 Polyclonal Lapin est utilisé pour la détection de CD43 dans des échantillons de Humain, Souris et Rat. Il a été validé pour FACS.

Aperçu rapide pour CD43 anticorps (AA 272-400) (APC) (ABIN8037216)

Antigène: CD43 (SPN) (Sialophorin (SPN))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CD43 est conjugé à/à la APC

Application: Flow Cytometry (FACS)

Détail du produit anti-CD43 anticorps (APC)

Épitope: AA 272-400

Fonction: Anti-CD43/SPN Antibody APC Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: Human CD43 shares 72%,73% amino acid (aa) sequences identity with mouse,rat CD43,respectively.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human CD43 recombinant protein (Position: A272-P400). Human CD43 shares 72% and 73% amino acid (aa) sequences identity with mouse and rat CD43, respectively.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur CD43

Antigène: CD43 (SPN) (Sialophorin (SPN))

Autre désignation: SPN

Sujet:

Background: CD43, also known as leukosialin or sialophorin, is a transmembrane cell surface protein that in humans is encoded by the SPN gene. It is mapped to 16p11.2. It is a major sialoglycoprotein on the surface of human T lymphocytes, monocytes, granulocytes, and some B lymphocytes, which is important for immune function and may be part of a physiologic ligand-receptor complex involved in T-cell activation. Expression of CD43 is deficient and/or defective in the X-chromosome-linked immunodeficiency disorder Wiscott-Aldrich syndrome, suggesting that CD43 have a role in T-cell activation. T-cell activation requires the removal of CD43 from the immunologic synapse to allow efficient engagement of the TCR with molecules on the APC.

Gene Full Name: sialophorin

Sequence Similarities: Contains 6 Ig-like C2-type (immunoglobulin-like) domains.

ID gène: 6693

UniProt: P16150

Pathways: Regulation of Leukocyte Mediated Immunity