STAMBPL1 anticorps (AA 187-436) (HRP)

N° du produit ABIN8042502

L’anticorps anti-STAMBPL1 Polyclonal Lapin est utilisé pour la détection de STAMBPL1 dans des échantillons de Humain et Souris. Il a été validé pour WB, ELISA et IHC.

Aperçu rapide pour STAMBPL1 anticorps (AA 187-436) (HRP) (ABIN8042502)

Antigène: STAMBPL1 (STAM Binding Protein-Like 1 (STAMBPL1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STAMBPL1 est conjugé à/à la HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-STAMBPL1 anticorps (HRP)

Épitope: AA 187-436

Fonction: Anti-AMSH-LP/STAMBPL1 Antibody HRP Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human AMSH-LP/STAMBPL1 recombinant protein (Position: Q187-R436).

Isotype: IgG

Information d'application

Indications d'application: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur STAMBPL1

Antigène: STAMBPL1 (STAM Binding Protein-Like 1 (STAMBPL1))

Autre désignation: STAMBPL1

Sujet:

Background: STAMBPL1 (STAM-binding protein-like 1), also known as AMSH-FP, AMSH-LP (associated molecule with the SH3 domain of STAM like protein) or ALMa, is a 436 amino acid protein that belongs to the peptidase M67C family, contains one MPN domain and a JAMM motif that is essential for protease activity. Existing as two alternatively spliced isoforms, STAMBPL1 is a ubiquitously expressed protein that binds two zinc ions per subunit and acts as a zinc metalloprotease that specifically cleaves Lys-63-linked polyubiquitin chains. The gene that encodes STAMBPL1 maps to human chromosome 10q23.31. Chromosome 10 contains over 800 genes and 135 million nucleotides, making up nearly 4.5 % of the human genome. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome. The chromosome 10 encoded gene ERCC6 is important for DNA repair and is linked to Cockayne syndrome which is characterized by extreme photosensitivity and premature aging. Tetrahydrobiopterin deficiency and a number of syndromes involving defective skull and facial bone fusion are also linked to chromosome 10.

Gene Full Name: STAM binding protein like 1

ID gène: 57559

UniProt: Q96FJ0