SWAP70 anticorps (AA 161-292) (PE)

N° du produit ABIN8044017

L’anticorps anti-SWAP70 Polyclonal Lapin est utilisé pour la détection de SWAP70 dans des échantillons de Humain. Il a été validé pour FACS.

Aperçu rapide pour SWAP70 anticorps (AA 161-292) (PE) (ABIN8044017)

Antigène: SWAP70 (SWAP Switching B-Cell Complex 70kDa Subunit (SWAP70))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SWAP70 est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Détail du produit anti-SWAP70 anticorps (PE)

Épitope: AA 161-292

Fonction: Anti-SWAP70 Antibody PE Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human SWAP70 recombinant protein (Position: H161-K292).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur SWAP70

Antigène: SWAP70 (SWAP Switching B-Cell Complex 70kDa Subunit (SWAP70))

Autre désignation: SWAP70

Sujet:

Background: SWAP70 (Switch-associated protein 70) is a 67-70 kDa intracellular protein that bears limited resemblance to members of the Dbl-family of GEFs for small Rho GTPases. It is expressed in mast cells, dendritic cells and B cells. In mast cells, it promotes the release of anaphylactic mediators, in dendritic cells, it regulates the appearance of MHC II, and in B cells, it forms a nuclear complex that initiates immunoglobulin class switching. Human SWAP70 is 585 amino acids (aa) in length. It contains one plextrin homology (PH) domain (aa 213-304) plus a coiled-coil region (aa 316-539). There are three potential splice variants. One contains an alternative start site at Met70, another shows a deletion of aa 81-138, and a third possesses a 38 aa substitution for aa 453-585. Over aa 386-585, human SWAP70 shares 96 % aa identity with mouse SWAP70.

Gene Full Name: switching B cell complex subunit SWAP70

ID gène: 23075

UniProt: Q9UH65

Pathways: Production of Molecular Mediator of Immune Response