TTC39B anticorps (AA 129-682) (Fluoro647)

N° du produit ABIN8045981

Cet anticorps Lapin Polyclonal détecte spécifiquement TTC39B dans FACS. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour TTC39B anticorps (AA 129-682) (Fluoro647) (ABIN8045981)

Antigène: TTC39B (Tetratricopeptide Repeat Domain 39B (TTC39B))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TTC39B est conjugé à/à la Fluoro647

Application: Flow Cytometry (FACS)

Détail du produit anti-TTC39B anticorps (Fluoro647)

Épitope: AA 129-682

Fonction: Anti-TTC39B Antibody Fluoro647 Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human TTC39B recombinant protein (Position: K129-D682).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur TTC39B

Antigène: TTC39B (Tetratricopeptide Repeat Domain 39B (TTC39B))

Autre désignation: TTC39B

Sujet:

Background: Tetratricopeptide repeat protein 39B is a protein that in humans is encoded by the TTC39B gene. TTC39B protein contains two TPR repeats (aa 39 3-426 and 626 -659). TCC39B protein is the product of a high density lipoprotein (HDL) gene that promotes the ubiquitination and degradation of liver X receptor (LXR). TTC39B null or deficient mice challenged with high fat/cholesterol/bile salt diet exhibit increased LX R protein and target gene expression. TTC39B deficiency is reported to stabilize LXR by reducing its polyubiquitination and proteasomal degradation. Hence it reduces the incidence of atherosclerosis and steatohepatitis. TTC39B deficiency mice display higher levels of HDL and Apoplipoprotein A-1 and lower levels of hepatic triglyceride synthesis.However it does not affect glucose tolerance or hepatic gluconeogenesis.

Gene Full Name: tetratricopeptide repeat domain 39B

ID gène: 158219

UniProt: Q5VTQ0