TPMT anticorps (AA 1-245) (Fluoro594)

N° du produit ABIN8046141

L’anticorps anti-TPMT Polyclonal Lapin est utilisé pour la détection de TPMT dans des échantillons de Humain, Souris et Rat. Il a été validé pour FACS.

Aperçu rapide pour TPMT anticorps (AA 1-245) (Fluoro594) (ABIN8046141)

Antigène: TPMT (Thiopurine S-Methyltransferase (TPMT))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TPMT est conjugé à/à la Fluoro594

Application: Flow Cytometry (FACS)

Détail du produit anti-TPMT anticorps (Fluoro594)

Épitope: AA 1-245

Fonction: Anti-TPMT Antibody Fluoro594 Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E. coli-derived human TPMT recombinant protein (Position: M1-K245).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur TPMT

Antigène: TPMT (Thiopurine S-Methyltransferase (TPMT))

Autre désignation: TPMT

Sujet:

Background: Thiopurine methyltransferase or thiopurine S-methyltransferase (TPMT) is an enzyme that in humans is encoded by the TPMT gene. This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.

Gene Full Name: thiopurine S-methyltransferase

ID gène: 7172

UniProt: P51580