TYMS anticorps (AA 1-313) (Fluoro488)

N° du produit ABIN8046524

Cet anticorps Lapin Polyclonal détecte spécifiquement TYMS dans FACS. Il présente une réactivité avec des échantillons de Humain, Rat et Singe.

Aperçu rapide pour TYMS anticorps (AA 1-313) (Fluoro488) (ABIN8046524)

Antigène: TYMS (Thymidylate Synthetase (TYMS))

Reactivité: Humain, Rat, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TYMS est conjugé à/à la Fluoro488

Application: Flow Cytometry (FACS)

Détail du produit anti-TYMS anticorps (Fluoro488)

Épitope: AA 1-313

Fonction: Anti-Thymidylate Synthase/TYMS Antibody Fluoro488 Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human Thymidylate Synthase/TYMS recombinant protein (Position: M1-V313).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur TYMS

Antigène: TYMS (Thymidylate Synthetase (TYMS))

Autre désignation: TYMS

Sujet:

Background: Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy.

Gene Full Name: thymidylate synthetase

ID gène: 7298

UniProt: P04818

Pathways: Mitotic G1-G1/S Phases