TFEB anticorps (AA 50-461) (Fluoro647)

N° du produit ABIN8047950

L’anticorps anti-TFEB Polyclonal Lapin est utilisé pour la détection de TFEB dans des échantillons de Humain, Souris et Rat. Il a été validé pour FACS.

Aperçu rapide pour TFEB anticorps (AA 50-461) (Fluoro647) (ABIN8047950)

Antigène: TFEB (Transcription Factor EB (TFEB))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TFEB est conjugé à/à la Fluoro647

Application: Flow Cytometry (FACS)

Détail du produit anti-TFEB anticorps (Fluoro647)

Épitope: AA 50-461

Fonction: Anti-TFEB Antibody Fluoro647 Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human TFEB recombinant protein (Position: T50-A461).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur TFEB

Antigène: TFEB (Transcription Factor EB (TFEB))

Autre désignation: TFEB

Sujet:

Background: Transcription factor EB is a protein that in humans is encoded by the TFEB gene. TFEB is a master gene for lysosomal biogenesis. It encodes a transcription factor that coordinates expression of lysosomal hydrolases, membrane proteins and genes involved in autophagy. Upon nutrient depletion and under aberrant lysosomal storage conditions such as in lysosomal storage diseases, TFEB translocates from the cytoplasm to the nucleus, resulting in the activation of its target genes. TFEB overexpression in cultured cells induces lysosomal biogenesis, exocytosis and autophagy. Viral-mediated TFEB overexpression in cellular and mouse models of lysosomal storage disorders and in common neurodegenerative diseases such as Huntington, Parkinson and Alzheimer diseases, resulted in intracellular clearance of accumulating molecules and rescue of disease phenotypes. TFEB is activated by PGC1-alpha and promotes reduction of htt aggregation and neurotoxicity in a mouse model of Huntington disease. TFEB overexpression has been found in patients with renal cell carcinoma and pancreatic cancer and was shown to promote tumorogenesis via induction of varius oncogenic signals.

Gene Full Name: transcription factor EB

ID gène: 7942

UniProt: P19484