MAFA anticorps (Middle Region) (PE)

N° du produit ABIN8047982

Cet anticorps Lapin Polyclonal détecte spécifiquement MAFA dans FACS. Il présente une réactivité avec des échantillons de Humain et Rat.

Aperçu rapide pour MAFA anticorps (Middle Region) (PE) (ABIN8047982)

Antigène: MAFA (Transcription Factor MafA (MAFA))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAFA est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Détail du produit anti-MAFA anticorps (PE)

Épitope: Middle Region

Fonction: Anti-Transcription factor MafA MAFA Antibody PE Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: identical to the related mouse sequence.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence in the middle region of human MAFA, identical to the related mouse sequence.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur MAFA

Antigène: MAFA (Transcription Factor MafA (MAFA))

Autre désignation: MAFA

Sujet:

Background: MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene. MAFA plays a key role in coordinating and controlling the level of insulin gene expression in islet beta cells. It is located in 8q24.3. The intracellular domain of MAFA contains a single immunoreceptor tyrosine-based inhibitory motif (ITIM), which classifies MAFA as a member of an inhibitory receptor superfamily. The inhibitory capacity of MAFA is best defined in mast cells, where MAFA keeps in check the antigen-induced (i.e. Fc epsilon RI-induced) secretion ofinflammatory mediators.

Gene Full Name: MAF bZIP transcription factor A

Sequence Similarities: Belongs to the bZIP family. Maf subfamily.

ID gène: 389692

UniProt: Q8NHW3

Pathways: Hormone Transport