Utrophin anticorps (AA 1211-2294) (FITC)

N° du produit ABIN8052944

Cet anticorps Lapin Polyclonal détecte spécifiquement Utrophin dans FACS. Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour Utrophin anticorps (AA 1211-2294) (FITC) (ABIN8052944)

Antigène: Utrophin (UTRN)

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Utrophin est conjugé à/à la FITC

Application: Flow Cytometry (FACS)

Détail du produit anti-Utrophin anticorps (FITC)

Épitope: AA 1211-2294

Fonction: Anti-Utrophin/UTRN Antibody FITC Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human Utrophin/UTRN recombinant protein (Position: L1211-K2294).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur Utrophin

Antigène: Utrophin (UTRN)

Autre désignation: UTRN

Sujet:

Background: Utrophin is a protein that in humans is encoded by the UTRN gene. This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described, however, the full-length nature of these variants has not yet been determined.

Gene Full Name: utrophin

ID gène: 7402

UniProt: P46939

Pathways: Skeletal Muscle Fiber Development