PROC anticorps (C-Term) (PE)

N° du produit ABIN8053772

Cet anticorps Lapin Polyclonal détecte spécifiquement PROC dans FACS. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour PROC anticorps (C-Term) (PE) (ABIN8053772)

Antigène: PROC (Vitamin K-dependent protein C (PROC))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PROC est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Détail du produit anti-PROC anticorps (PE)

Épitope: C-Term

Fonction: Anti-Protein C/PROC Antibody PE Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human Protein C.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur PROC

Antigène: PROC (Vitamin K-dependent protein C (PROC))

Autre désignation: PROC

Sujet:

Background: Protein C (PROC), also called PC, is a zymogenic (inactive) protein, the activated form of which plays an important role in regulating blood clotting, inflammation, cell death and maintaining the permeability of blood vessel walls in humans and other animals. The PROC gene is mapped on 2q14.3. The PROC gene contains 8 exons and spans about 11 kb by Foster et al. The conversion of protein C to a protease with anticoagulant function by thrombin requires as a cofactor thrombomodulin, an endothelial cell membrane protein. Riewald et al. demonstrated that activated protein C uses the endothelial cell protein C receptor as a coreceptor for cleavage of protease-activated receptor-1 on endothelial cells. Faust et al. demonstrated that the endothelial pathways required for protein C activation are impaired in severe meningococcal sepsis. They stated that improvement in the outcome of children with meningococcal sepsis who were treated with unactivated protein C concentrates had been described in case reports and in 1 uncontrolled series.

Gene Full Name: protein C, inactivator of coagulation factors Va and VIIIa

Sequence Similarities: Belongs to the peptidase S1 family.

ID gène: 5624

UniProt: P04070