ZBTB48 anticorps (AA 1-623) (Biotin)

N° du produit ABIN8055108

L’anticorps anti-ZBTB48 Polyclonal Lapin est utilisé pour la détection de ZBTB48 dans des échantillons de Humain. Il a été validé pour WB, ELISA et IHC.

Aperçu rapide pour ZBTB48 anticorps (AA 1-623) (Biotin) (ABIN8055108)

Antigène: ZBTB48 (Zinc Finger and BTB Domain Containing 48 (ZBTB48))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZBTB48 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-ZBTB48 anticorps (Biotin)

Épitope: AA 1-623

Fonction: Anti-ZBTB48 Antibody Biotin Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human ZBTB48 recombinant protein (Position: M1-M623).

Isotype: IgG

Information d'application

Indications d'application: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur ZBTB48

Antigène: ZBTB48 (Zinc Finger and BTB Domain Containing 48 (ZBTB48))

Autre désignation: ZBTB48

Sujet:

Background: Zinc finger and BTB domain containing 48 (ZBTB48), also known as telomeric zinc-finger associated protein (TZAP), is a protein that ly binds to the double-stranded repeat sequence of telomeres. In humans it is encoded by the ZBTB48 gene. ZBTB48, also named as TZAP and HKR3, is a 688 amino acid protein, which contains 1 BTB (POZ) domain and 11 C2H2-type zinc fingers and belongs to the krueppel C2H2-type zinc-finger protein family. ZBTB48 is detected in adrenal gland and neuroblastoma. ZBTB48 binds to and regulates the J and/or S elements in MHC II promoter. Zinc finger and BTB domain containing 48 (ZBTB48), also known as telomeric zinc-finger associated protein (TZAP), is a protein that triggers the trimming of telomeres in the absence of shelterin. ZBTB48, is a relatively uncharacterized POK family protein with a POZ-domain and 11 zinc finger domains. ZBTB48, is ubiquitously expressed in human tissues. The ZBTB48 gene is mapped to human chromosome 1p36, which is commonly rearranged (leiomyoma and leukemias) or deleted in various cancers (neuroblastoma, melanoma, Merkel cell carcinomas, pheochromocytoma and breast and colon carcinomas. A correlation between deletions or rearrangements of HKR3 and human cancer suggest a role for ZBTB48 as a potential tumor suppressor.

Gene Full Name: zinc finger and BTB domain containing 48

ID gène: 3104

UniProt: P10074