ZBTB7A anticorps (N-Term) (FITC)

N° du produit ABIN8055146

Cet anticorps Lapin Polyclonal détecte spécifiquement ZBTB7A dans FACS. Il présente une réactivité avec des échantillons de Souris et Rat.

Aperçu rapide pour ZBTB7A anticorps (N-Term) (FITC) (ABIN8055146)

Antigène: ZBTB7A (Zinc Finger and BTB Domain Containing 7A (ZBTB7A))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZBTB7A est conjugé à/à la FITC

Application: Flow Cytometry (FACS)

Détail du produit anti-ZBTB7A anticorps (FITC)

Épitope: N-Term

Fonction: Anti-ZBTB7A Antibody FITC Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins.

Homologie: different from the related human sequence by eleven amino acids,and from the related rat sequence by one amino acid.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of mouse ZBTB7A, different from the related human sequence by eleven amino acids, and from the related rat sequence by one amino acid.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur ZBTB7A

Antigène: ZBTB7A (Zinc Finger and BTB Domain Containing 7A (ZBTB7A))

Autre désignation: Zbtb7a

Sujet:

Background: Zinc finger and BTB domain-containing protein 7A is a protein that in humans is encoded by the ZBTB7A gene. ZBTB7A has a critical oncosuppressive role in the prostate. Prostate-specific inactivation of ZBTB7A leads to a marked acceleration of PTEN loss-driven prostate tumorigenesis through bypass of PTEN loss-induced cellular senescence. It has been showed that ZBTB7A physically interacts with SOX9 and functionally antagonizes its transcriptional activity on key target genes such as MIA, which is involved in tumor cell invasion, and H19, a long noncoding RNA precursor for an RB-targeting microRNA. Inactivation of ZBTB7A in vivo leads to RB downregulation, bypass of PTEN loss-induced cellular senescence, and invasive prostate cancer. Notably, it has been also found that ZBTB7A is genetically lost, as well as downregulated at both the mRNA and protein levels, in a subset of human advanced prostate cancers. Therefore, ZBTB7A is identified as a context-dependent cancer gene that can act as an oncogene in some contexts but that also has oncosuppressive-like activity in PTEN-null tumors.

Gene Full Name: zinc finger and BTB domain containing 7a

ID gène: 16969

UniProt: O88939