ZEB2 anticorps (C-Term) (Fluoro647)

N° du produit ABIN8055216

L’anticorps anti-ZEB2 Polyclonal Lapin est utilisé pour la détection de ZEB2 dans des échantillons de Humain, Souris et Rat. Il a été validé pour FACS.

Aperçu rapide pour ZEB2 anticorps (C-Term) (Fluoro647) (ABIN8055216)

Antigène: ZEB2 (Zinc Finger E-Box Binding Homeobox 2 (ZEB2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZEB2 est conjugé à/à la Fluoro647

Application: Flow Cytometry (FACS)

Détail du produit anti-ZEB2 anticorps (Fluoro647)

Épitope: C-Term

Fonction: Anti-Smad Interacting Protein 1/ZEB2 Antibody Fluoro647 Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: identical to the related rat,mouse sequences.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human ZEB2, identical to the related rat and mouse sequences.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur ZEB2

Antigène: ZEB2 (Zinc Finger E-Box Binding Homeobox 2 (ZEB2))

Autre désignation: ZEB2

Sujet:

Background: ZEB2 (Zinc finger E-box-binding homeobox2), also known as SIP1or ZINC FINGER HOMEOBOX 1B (ZFHX1B), is a protein that in humans is encoded by the ZEB2 gene. The ZEB2 gene is a member of the ZEB1/Drosophila Zfh1 family of 2-handed zinc finger/homeodomain proteins and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs, the transducers of TGF-beta signaling, and interacts with the nucleosome remodeling and histone deacetylation (NURD) complex. By radiation hybrid analysis, Nagase et al. (1998) mapped the ZEB2 gene to chromosome 2. Wakamatsu et al. (2001) mapped the ZEB2 gene to chromosome 2q22. Vandewalle et al. (2005) showed that expression of mouse Sip1 in human epithelial cells caused a morphologic change from an epithelial to a mesenchymal phenotype. Expression of SNAI1 in epithelial cells triggers an epithelial-mesenchyme transition. Beltran et al. (2008) showed that synthesis of ZEB2 was upregulated following SNAI1 expression in human cell lines.

Gene Full Name: zinc finger E-box binding homeobox 2

Sequence Similarities: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

ID gène: 9839

UniProt: O60315

Pathways: Tube Formation