PATZ1 anticorps (AA 145-680) (FITC)

N° du produit ABIN8055223

Cet anticorps anti-PATZ1 Polyclonal Lapin conjugué à FITC (ABIN8055223) détecte spécifiquement PATZ1 dans FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour PATZ1 anticorps (AA 145-680) (FITC) (ABIN8055223)

Antigène: PATZ1 (ZNF278) (Zinc Finger Protein 278 (ZNF278))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PATZ1 est conjugé à/à la FITC

Application: Flow Cytometry (FACS)

Détail du produit anti-PATZ1 anticorps (FITC)

Épitope: AA 145-680

Fonction: Anti-PATZ1 Antibody FITC Conjugated

Réactivité croisée (Details): No cross reactivity with other proteins.

Homologie: Human PATZ1 shares 98.9% amino acid (aa) sequence identity with mouse PATZ1.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human PATZ1 recombinant protein (Position: M145-Q680). Human PATZ1 shares 98.9% amino acid (aa) sequence identity with mouse PATZ1.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur PATZ1

Antigène: PATZ1 (ZNF278) (Zinc Finger Protein 278 (ZNF278))

Autre désignation: PATZ1

Sujet:

Background: POZ-, AT hook-, and zinc finger-containing protein 1 is a protein that in humans is encoded by the PATZ1 gene. The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1,22)(p36.1,q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene.

Gene Full Name: POZ/BTB and AT hook containing zinc finger 1

ID gène: 23598

UniProt: Q9HBE1