D-Dimer anticorps

N° du produit ABIN8065445

Cet anticorps Souris Monoclonal détecte spécifiquement D-Dimer dans ELISA et WB. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour D-Dimer anticorps (ABIN8065445)

Antigène: D-Dimer

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp D-Dimer est non-conjugé

Application: ELISA, Western Blotting (WB)

Classe de qualité: Carrier-free

Clone: 22

Détail du produit anti-D-Dimer anticorps

Fonction: Anti-D-Dimer Antibody

Specificité: ABS 015-22 binds human D-dimer. Cross-reacts < 2 % with directly coated D-monomer but not with directly coated fibrinogen. When tested in a pair with itself, with ABS 015-28 and with a fibrinogen-specific polyclonal antibody, the epitope appears to relate to the dimerization site of D-dimer.

Homologie: Canine,Human

Purification: Protein A or Protein G purified

Immunogène: Purified human D-dimer

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: 2-8°C without exposure to light

Date de péremption: 24 months

Détails sur D-Dimer

Antigène: D-Dimer

Sujet: FGA, AMYLD2, Fib2, fibrinogen alpha chain, fibrinogen, A alpha polypeptide, FGB, HEL-S-78p, fibrinogen beta chain, beta-fibrinogen, epididymis secretory sperm binding protein Li 78p, fibrinogen, B beta polypeptide, FGG, fibrinogen gamma chain, fibrinogen, gamma polypeptide, testicular tissue protein Li 70,Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways,FGA, FGB, FGG,D-dimer is a fibrin degradation product, a small protein fragment present in the blood after a blood clot is degraded by fibrinolysis.

Poids moléculaire: 180 kDa

ID gène: 2243, 2244, 2266

UniProt: P02671, P02675, P02679