Ghrelin anticorps

N° du produit ABIN8065476

L’anticorps anti-Ghrelin Monoclonal Souris est utilisé pour la détection de Ghrelin dans des échantillons de Humain. Il a été validé pour WB et ELISA.

Aperçu rapide pour Ghrelin anticorps (ABIN8065476)

Antigène: Ghrelin (GHRL)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Ghrelin est non-conjugé

Application: Western Blotting (WB), ELISA

Classe de qualité: Carrier-free

Clone: 121

Détail du produit anti-Ghrelin anticorps

Fonction: Anti-Ghrelin Antibody

Specificité: ABS 052-121 binds human ghrelin.

Homologie: Canine,Feline,Human,Mouse,and Rat

Purification: Protein A or Protein G purified

Immunogène: Synthetic ghrelin (14-28)

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: 2-8°C without exposure to light

Date de péremption: 24 months

Détails sur Ghrelin

Antigène: Ghrelin (GHRL)

Autre désignation: Ghrelin

Sujet: GHRL, MTLRP, appetite-regulating hormone, In2c-preproghrelin, ghrelin, growth hormone secretagogue receptor ligand, ghrelin/obestatin preprohormone, ghrelin/obestatin prepropeptide, growth hormone-releasing peptide, motilin-related peptide, prepro-appetite regulatory hormone, preproghrelin,Precursor of the appetite-regulating peptide ghrelin, including ghrelin-27 and ghrelin-28. {ECO:0000269|PubMed:11306336, ECO:0000269|PubMed:35027551}., [Ghrelin-27]: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR) (PubMed:10604470, PubMed:35027551). Induces the release of growth hormone from the pituitary (PubMed:10604470). Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. {ECO:0000269|PubMed:10604470, ECO:0000269|PubMed:35027551}., [Ghrelin-28]: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR) (PubMed:10604470, PubMed:35027551). Octanoylated ghrelin-28 is the most commonly found ghrelin and octanoylation is essential for the activation of the growth hormone secretagogue receptor type 1 (GHSR) (PubMed:11306336, PubMed:35027551). Induces the release of growth hormone from the pituitary (PubMed:10604470). Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. {ECO:0000269|PubMed:10604470, ECO:0000269|PubMed:11306336, ECO:0000269|PubMed:35027551}., [Obestatin]: May be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity). {ECO:0000250}.,GHRL,Ghrelin is an orexigenic (food intake stimulating) 27 or 28 amino-acid gut-brain peptide hormone produced by endocrine cells in the stomach, pancreatic islets and certain hypothalamic neurons. Two forms are produced by alternative mRNA splicing, Gln13 or 14 is missing from the second form. "Active" ghrelin is acylated (octanoylated) at Ser3, this form stimulates growth hormone secretion via GHS receptors and increases appetite. The des-acyl form does not have these effects but may have other actions. Plasma responses of total ghrelin to food reflect those of active ghrelin.

Poids moléculaire: 13 kDa (pro-ghrelin), 6 kDa (mature ghrelin)

ID gène: 51738

UniProt: Q9UBU3

Pathways: Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Peptide Hormone Metabolism, Negative Regulation of Hormone Secretion, Synaptic Membrane, Feeding Behaviour