OXM anticorps

N° du produit ABIN8065513

Cet anticorps anti-OXM Monoclonal Souris (Clone 23) (ABIN8065513) détecte spécifiquement OXM dans ELISA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour OXM anticorps (ABIN8065513)

Antigène: OXM (Oxyntomodulin (OXM))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp OXM est non-conjugé

Application: ELISA

Classe de qualité: Carrier-free

Clone: 23

Détail du produit anti-OXM anticorps

Fonction: Anti-Oxyntomodulin Antibody

Specificité: ABS 064-23 is specific for C-terminus of human oxyntomodulin. Does not cross-react with glucagon. ABS 064-23 has a different epitope specificity compared to ABS 059-20 and ABS 064-46.

Homologie: Human,Mouse,and Rat

Purification: Protein A or Protein G purified

Immunogène: Synthetic oxyntomodulin 31-37 coupled to carrier.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: 2-8°C without exposure to light

Date de péremption: 24 months

Détails sur OXM

Antigène: OXM (Oxyntomodulin (OXM))

Autre désignation: Oxyntomodulin

Sujet: GCG, GLP-1, GLP1, GLP2, GRPP, pro-glucagon, glicentin-related polypeptide, glucagon-like peptide 1, glucagon-like peptide 2, incretin, preproglucagon,Glucagon-like peptide 1. Potent stimulator of glucose-dependent insulin release (PubMed:22037645, PubMed:40446798). Also stimulates insulin release in response to IL6 (PubMed:22037645). Plays important roles on gastric motility and the suppression of plasma glucagon levels (PubMed:10605628, PubMed:14719035, PubMed:12554744). May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin (PubMed:10605628, PubMed:14719035, PubMed:12554744). Has growth-promoting activities on intestinal epithelium (PubMed:10605628, PubMed:14719035, PubMed:12554744). May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion (PubMed:10605628, PubMed:14719035, PubMed:12554744). Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation (PubMed:10605628, PubMed:14719035, PubMed:12554744). Inhibits beta cell apoptosis (PubMed:10605628, PubMed:14719035, PubMed:12554744).,GCG,Oxyntomodulin is a peptide hormone of 37 amino-acid residues (29-amino acid sequence of glucagon, with an 8-amino acid carboxy-terminal extension) produced by the L cells of the gut. It modulates gastric acid secretion from the oxyntic cells of the stomach, inhibits appetite and has glucose lowering effects. Oxyntomodulin is produced by cell-type-specific processing of proglucagon that forms as well glicentin, GLP-1 and GLP-2 in the L cells of the intestinal mucosa.

Poids moléculaire: 20 kDa

ID gène: 2641

UniProt: P01275