Peptide Histidine-Methionine anticorps

N° du produit ABIN8065516

Cet anticorps anti-Peptide Histidine-Methionine Monoclonal Souris (Clone 3) (ABIN8065516) détecte spécifiquement Peptide Histidine-Methionine dans ELISA et IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Peptide Histidine-Methionine anticorps (ABIN8065516)

Antigène: Peptide Histidine-Methionine (PHM)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Peptide Histidine-Methionine est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Classe de qualité: Carrier-free

Clone: 3

Détail du produit anti-Peptide Histidine-Methionine anticorps

Fonction: Anti-Peptide Histidine Methionine Antibody

Specificité: ABS 020-03 binds human PHM and cross-reacts with PACAP (approximately 12 % , incomplete, non-parallel inhibition). ABS 020-03 does not cross-react with GLP-1, GLP-2, VIP or glucagon.

Homologie: Human

Purification: Protein A or Protein G purified

Immunogène: Synthetic human peptide histidine-methionine

Isotype: IgG2a, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: 2-8°C without exposure to light

Date de péremption: 24 months

Détails sur Peptide Histidine-Methionine

Antigène: Peptide Histidine-Methionine (PHM)

Autre désignation: Peptide Histidine Methionine

Sujet: VIP, PHM27, VIP peptides, prepro-VIP,[Vasoactive intestinal peptide]: VIP is a neuropeptide involved in a diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VPR1) and VIP receptor 2 (VPR2) (PubMed:1318039, PubMed:36385145, PubMed:8933357). Abundantly expressed throughout the CNS and peripheral nervous systems where they primarily exert neuroprotective and immune modulatory roles (PubMed:3456568). Also causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder (PubMed:15013843). {ECO:0000269|PubMed:1318039, ECO:0000269|PubMed:15013843, ECO:0000269|PubMed:3456568, ECO:0000269|PubMed:36385145, ECO:0000269|PubMed:8933357}., [Intestinal peptide PHM-27]: Bioactive forms that cause vasodilation (PubMed:15013843, PubMed:3654650). PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin (PubMed:15013843). {ECO:0000269|PubMed:15013843, ECO:0000269|PubMed:3654650}., [Intestinal peptide PHV-42]: Bioactive forms that cause vasodilation (PubMed:15013843, PubMed:3654650). {ECO:0000269|PubMed:15013843, ECO:0000269|PubMed:3654650}.,VIP,Human peptide histidine-methionine (PHM) is a 27 amino acid peptide belonging to the glucagon-secretin family of peptide hormones. PHM is produced from the same prohormone as VIP, with which it shows considerable sequence homology. The VIP/PHM prohormone is produced by neurons in the central and peripheral nervous systems, often together with acetylcholine. In some situations the effect of the peptides is to reinforce and prolong the effects of neurotransmitter release. Like VIP, PHM is a vasodilator and stimulator of intestinal fluid secretion. High plasma levels of PHM are diagnostic of the corresponding peptide-producing tumor (VIPoma), associated with the watery diarrhea-hypokalemia-achlorhydria syndrome.

Poids moléculaire: 3 kDa

ID gène: 7432

UniProt: P01282