PAPPA anticorps

N° du produit ABIN8065520

Cet anticorps Souris Monoclonal détecte spécifiquement PAPPA dans IHC, WB et ELISA. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour PAPPA anticorps (ABIN8065520)

Antigène: PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PAPPA est non-conjugé

Application: Immunohistochemistry (IHC), Western Blotting (WB), ELISA

Classe de qualité: Carrier-free

Clone: PAPP A 1-1

Détail du produit anti-PAPPA anticorps

Fonction: Anti-Pregnancy Associated Plasma Protein A (PAPP-A) Antibody

Specificité: ABIN8065520 is specific for native human PAPP-A. The epitope of ABIN8065520 is different from ABIN8065522 and ABIN8065521. The epitope is located on the PAPP-A subunit of the heterotetramer.

Homologie: Human

Purification: Protein A or Protein G purified

Immunogène: Purified human PAPP-A

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: 2-8°C without exposure to light

Date de péremption: 24 months

Détails sur PAPPA

Antigène: PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))

Autre désignation: Pregnancy Associated Plasma Protein A

Sujet: PAPPA, ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A, PAPPA1, pappalysin-1, IGF-dependent IGFBP-4 protease, aspecific BCL2 ARE-binding protein 2, differentially placenta 1 expressed protein, insulin-like growth factor-dependent IGF binding protein-4 protease, pregnancy-associated plasma protein A, pappalysin 1,Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. {ECO:0000269|PubMed:10077652, ECO:0000269|PubMed:10913121, ECO:0000269|PubMed:11522292}.,PAPPA,Pregnancy-associated plasma protein-A (PAPP-A, Insulin-like growth factor binding protein-4 protease, PAPP-A-proMBP complex) is a large heterotetrameric glycoprotein of approximately 500 kDa, which was first discovered in serum from pregnant women. The hetreotetramer consists of two PAPP-A subunits and two proMBP subunits. Low maternal serum levels of PAPP-A in first trimester biochemical screening is used as a marker of Down's syndrome (trisomy 21).

Poids moléculaire: 500 kDa (tetramer), 180 kDa (monomer)

ID gène: 5069

UniProt: Q13219