Vip anticorps

N° du produit ABIN8065532

Cet anticorps Souris Monoclonal détecte spécifiquement Vip dans WB, IHC, ELISA et IF. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Vip anticorps (ABIN8065532)

Antigène: Vip (Vasoactive Intestinal Peptide (Vip))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Vip est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Classe de qualité: Carrier-free

Clone: 2

Détail du produit anti-Vip anticorps

Fonction: Anti-Vasoactive Intestinal Peptide Antibody

Specificité: ABS 023-02 binds to human, bovine, porcine or rat VIP, but does not bind to PHM or PACAP.

Homologie: Bovine,Human,Pig,and Rat

Purification: Protein A or Protein G purified

Immunogène: Vasoactive intestinal peptide

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: 2-8°C without exposure to light

Date de péremption: 24 months

Détails sur Vip

Antigène: Vip (Vasoactive Intestinal Peptide (Vip))

Autre désignation: Vasoactive Intestinal Peptide

Sujet: VIP, PHM27, VIP peptides, prepro-VIP,[Vasoactive intestinal peptide]: VIP is a neuropeptide involved in a diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VPR1) and VIP receptor 2 (VPR2) (PubMed:1318039, PubMed:36385145, PubMed:8933357). Abundantly expressed throughout the CNS and peripheral nervous systems where they primarily exert neuroprotective and immune modulatory roles (PubMed:3456568). Also causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder (PubMed:15013843). {ECO:0000269|PubMed:1318039, ECO:0000269|PubMed:15013843, ECO:0000269|PubMed:3456568, ECO:0000269|PubMed:36385145, ECO:0000269|PubMed:8933357}., [Intestinal peptide PHM-27]: Bioactive forms that cause vasodilation (PubMed:15013843, PubMed:3654650). PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin (PubMed:15013843). {ECO:0000269|PubMed:15013843, ECO:0000269|PubMed:3654650}., [Intestinal peptide PHV-42]: Bioactive forms that cause vasodilation (PubMed:15013843, PubMed:3654650). {ECO:0000269|PubMed:15013843, ECO:0000269|PubMed:3654650}.,VIP,Vasoactive intestinal peptide (VIP) is a 28 amino acid peptide belonging to the secretin-glucagon family of peptide hormones. Its sequence is identical in humans, cows, pigs and rats. VIP is widely distributed in the central and peripheral nervous systems, acting as a neurotransmitter or neuromodulator. Peripherally it is involved in vaso- and bronchodilatation, smooth muscle relaxation and stimulation of secretion. Ectopic endocrine tumors secreting VIP (VIPomas) give rise to raised plasma levels of VIP and are associated with watery diarrhea, hypokalemia and achlorhydria syndrome. VIP shows high sequence homology with peptide histidine-methionine (PHM) in humans or peptide histidine-serine (PHI) in pigs or rats, present in the same precursor, and with the neuropeptide pituitary adenylate cyclase activating polypeptide (PACAP).

Poids moléculaire: 16 kDa (recombinant/precursor), 4 kDa (native/active)

ID gène: 7432

UniProt: P01282

Pathways: Hormone Activity, cAMP Metabolic Process