Recombinant CD39 anticorps

N° du produit ABIN8093139

Cet anticorps anti-CD39 Monoclonal Souris (Clone r22A9) (ABIN8093139) détecte spécifiquement CD39 dans IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant CD39 anticorps (ABIN8093139)

Antigène: CD39 (ENTPD1) (Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD39 est non-conjugé

Application: Immunohistochemistry (IHC)

Classe de qualité: Carrier-free

Clone: R22A9

Détail du produit anti-CD39 anticorps

Fonction: CD39 Antibody / ENTPD1 (azide and preservative free)

Immunogène: Prokaryotic recombinant protein corresponding to a portion of the external domain of the CD39 molecule was used as the immunogen for the ENTPD1/Ectonucleoside triphosphate diphosphohydrolase 1 antibody.

Isotype: IgG2a, kappa

Information d'application

Indications d'application: 1. Optimal dilution of the ENTPD1/Ectonucleoside triphosphate diphosphohydrolase 1 antibody should be determined by the researcher.

2. This ENTPD1/Ectonucleoside triphosphate diphosphohydrolase 1 antibody is recombinantly produced by expression in CHO cells.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: ENTPD1/Ectonucleoside triphosphate diphosphohydrolase 1 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Détails sur CD39

Antigène: CD39 (ENTPD1) (Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1))

Autre désignation: CD39

Sujet: ENTPD1 Antibody recognizes CD39, also known as Ectonucleoside triphosphate diphosphohydrolase 1, a plasma membrane ectoenzyme that regulates extracellular nucleotide signaling. Encoded by the ENTPD1 gene, CD39 hydrolyzes extracellular ATP and ADP to AMP, thereby modulating purinergic signaling pathways involved in inflammation, thrombosis, and immune regulation. ENTPD1 Antibody is suitable for detecting CD39 expression in research applications focused on immune homeostasis and tumor microenvironment biology.

ENTPD1 antibody, also referred to as CD39 antibody and NTPDase1 antibody in the literature, targets a glycosylated transmembrane protein expressed on endothelial cells, regulatory T cells, B cells, monocytes, macrophages, and selected epithelial populations. By limiting extracellular ATP and cooperating with CD73 to generate adenosine, CD39 contributes to immunosuppressive signaling pathways that regulate lymphocyte activation and maintain vascular homeostasis. Increased CD39 expression has been associated with immune tolerance and tumor-associated immune suppression.

The ENTPD1 gene is located on chromosome 10q24.1 and encodes a protein containing two transmembrane regions and a large extracellular catalytic domain with conserved apyrase motifs required for nucleotide hydrolysis. CD39 localizes predominantly to the plasma membrane and demonstrates membranous staining in endothelial and immune cell populations in tissue sections. Expression is particularly prominent in lymphoid tissues such as tonsil and lymph node, as well as in vascular endothelium and placenta.

Dysregulation of ENTPD1 expression has been implicated in cancer progression, chronic inflammatory disease, thrombosis, and cardiovascular disorders. Clone r22A9 is a recombinant mouse monoclonal antibody developed to recognize ENTPD1 / CD39 in experimental systems.

UniProt: P49961