EGFL7 anticorps (AA 1-200)

N° du produit ABIN8093140

Cet anticorps Souris Monoclonal détecte spécifiquement EGFL7 dans WB et IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour EGFL7 anticorps (AA 1-200) (ABIN8093140)

Antigène: EGFL7 (EGF-Like-Domain, Multiple 7 (EGFL7))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp EGFL7 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: EGFL7-9497

Détail du produit anti-EGFL7 anticorps

Épitope: AA 1-200

Fonction: EGFL7 Antibody / EGF-like domain-containing protein 7

Immunogène: A recombinant fragment (around amino acids 1-200) of human EGFL7 protein (exact sequence is proprietary) was used as the immuongen for the EGFL7/EGF-like domain-containing protein 7 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the EGFL7/EGF-like domain-containing protein 7 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: EGFL7/EGF-like domain-containing protein 7 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Détails sur EGFL7

Antigène: EGFL7 (EGF-Like-Domain, Multiple 7 (EGFL7))

Autre désignation: EGFL7

Sujet: EGFL7 antibody, also known as EGF-like domain-containing protein 7 antibody, recognizes a secreted extracellular matrix-associated protein commonly referred to as Epidermal growth factor-like protein 7 and Vascular endothelial statin. EGF-like domain-containing protein 7 is encoded by the EGFL7 gene located on chromosome 9q34 and is predominantly expressed by endothelial cells. The protein is secreted into the extracellular space, where it associates with the vascular basement membrane and plays an important role in angiogenesis and vascular development. EGFL7 expression is particularly prominent during embryogenesis and in actively remodeling vasculature.

EGF-like domain-containing protein 7 functions as a regulator of endothelial cell adhesion, migration, and tubulogenesis. It contributes to vascular lumen formation and maintains endothelial integrity by modulating interactions between endothelial cells and the extracellular matrix. EGFL7 antibody is commonly used in studies investigating angiogenesis, vascular morphogenesis, and tumor-associated neovascularization. The protein is also implicated in Notch signaling modulation, influencing endothelial differentiation and vascular patterning.

Structurally, EGF-like domain-containing protein 7 contains multiple epidermal growth factor-like repeats that mediate protein-protein interactions within the extracellular matrix. Through these domains, EGFL7 interacts with integrins and other matrix components to regulate endothelial cell behavior. Its expression is tightly controlled during development, with high levels observed in embryonic vasculature and reduced expression in most normal adult tissues, except in sites of active vascular remodeling or repair.

Dysregulated EGFL7 expression has been associated with tumor progression and metastasis. Elevated levels are observed in various cancers, including colorectal, breast, and hepatocellular carcinoma, where increased vascularization supports tumor growth. Because EGFL7 is largely endothelial-specific, it serves as a useful marker for studying tumor vasculature and angiogenic processes. Its extracellular localization also makes it of interest in therapeutic targeting strategies aimed at modulating angiogenesis.

EGFL7 antibody supports research into vascular biology, developmental angiogenesis, and tumor microenvironment signaling. Clone EGFL7/9497 recognizes EGF-like domain-containing protein 7 and is suitable for detecting EGFL7 expression in relevant research applications.

UniProt: Q9UHF1