HNF1B anticorps (AA 1-200)

N° du produit ABIN8093246

L’anticorps anti-HNF1B Monoclonal Souris est utilisé pour la détection de HNF1B dans des échantillons de Humain. Il a été validé pour IHC.

Aperçu rapide pour HNF1B anticorps (AA 1-200) (ABIN8093246)

Antigène: HNF1B (HNF1 Homeobox B (HNF1B))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HNF1B est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: HNF1B-9519

Détail du produit anti-HNF1B anticorps

Épitope: AA 1-200

Fonction: HNF1B Antibody / Transcription factor HNF1 beta

Immunogène: A recombinant fragment (around amino acids 1-200) of human HNF1B protein (exact sequence is proprietary) was used as the immunogen for the TCF2/HNF1B antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the TCF2/HNF1B antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: TCF2/HNF1B antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Détails sur HNF1B

Antigène: HNF1B (HNF1 Homeobox B (HNF1B))

Autre désignation: HNF1B

Sujet: TCF2 antibody, also known as Hepatocyte nuclear factor 1 beta antibody, recognizes a homeodomain-containing transcription factor encoded by the HNF1B gene. This protein is commonly referred to as HNF1 beta and was historically described as TCF2 in early genetic studies. HNF1B is a nuclear transcription factor that regulates gene expression during embryonic development and adult tissue homeostasis, particularly in liver, kidney, pancreas, and genitourinary epithelium.

HNF1B belongs to the homeodomain-containing transcription factor family and functions as either a homodimer or heterodimer with HNF1A. It binds specific DNA promoter sequences and regulates genes involved in epithelial differentiation, glucose metabolism, and organ morphogenesis. The protein contains a dimerization domain, a POU-specific DNA binding domain, and a transactivation domain that mediates transcriptional regulation of downstream targets.

During development, HNF1B plays a critical role in renal tubulogenesis, pancreatic organogenesis, and hepatobiliary differentiation. It is highly expressed in renal tubular epithelial cells, bile ducts, pancreatic ductal cells, and certain epithelial-derived tissues. Disruption of HNF1B expression alters nephron segmentation and epithelial polarity, highlighting its role in tissue architecture and functional maturation.

Clinically, mutations in HNF1B are associated with Renal cysts and diabetes syndrome, also known as MODY5, as well as congenital abnormalities of the kidney and urinary tract. Loss or altered expression has also been described in subsets of renal cell carcinoma and gynecologic malignancies. Because of its consistent nuclear localization and epithelial lineage specificity, TCF2 antibody is widely used for evaluating HNF1B expression in developmental biology and oncology research.

In normal tissues, HNF1B localizes predominantly to the nucleus, consistent with its transcription factor function. Altered nuclear expression patterns may reflect dysregulation of epithelial differentiation programs. A TCF2 antibody can be used in research applications to detect HNF1B protein expression in relevant experimental systems.

UniProt: P35680

Pathways: Hormone Transport, Stem Cell Maintenance, Tube Formation