HSD17B13 anticorps (AA 1-200)

N° du produit ABIN8093248

Cet anticorps Souris Monoclonal détecte spécifiquement HSD17B13 dans WB et IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour HSD17B13 anticorps (AA 1-200) (ABIN8093248)

Antigène: HSD17B13 (Hydroxysteroid (17-Beta) Dehydrogenase 13 (HSD17B13))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HSD17B13 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: HSD17B13-13105

Détail du produit anti-HSD17B13 anticorps

Épitope: AA 1-200

Fonction: HSD17B13 Antibody / Hydroxysteroid 17 beta dehydrogenase 13

Immunogène: A recombinant fragment (around amino acids 1-200) of human HSD17B13 protein (exact sequence is proprietary) was used as the immunogen for the HSD17B13/Hydroxysteroid 17 beta dehydrogenase 13 antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the HSD17B13/Hydroxysteroid 17 beta dehydrogenase 13 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: HSD17B13/Hydroxysteroid 17 beta dehydrogenase 13 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Détails sur HSD17B13

Antigène: HSD17B13 (Hydroxysteroid (17-Beta) Dehydrogenase 13 (HSD17B13))

Autre désignation: HSD17B13

Sujet: HSD17B13 antibody targets Hydroxysteroid 17 beta dehydrogenase 13, a liver-enriched enzyme encoded by the HSD17B13 gene that belongs to the hydroxysteroid dehydrogenase family. Hydroxysteroid 17 beta dehydrogenase 13 is predominantly localized to the cytoplasm and lipid droplet-associated compartments of hepatocytes, where it participates in hepatic lipid metabolism and steroid-related redox processes. Because of its strong liver specificity, an HSD17B13 antibody is widely used in studies of liver biology and metabolic disease.

Hydroxysteroid 17 beta dehydrogenase 13 is structurally related to other 17 beta-hydroxysteroid dehydrogenases but displays distinct substrate specificity and tissue distribution. It contains a conserved short-chain dehydrogenase reductase domain, supporting enzymatic activity linked to lipid and steroid metabolism. In hepatocytes, HSD17B13 associates with lipid droplets and is thought to modulate lipid storage and turnover, making antibody-based detection valuable for investigating hepatocellular metabolic regulation.

Genetic studies have identified HSD17B13 as a key modifier of liver disease risk. Specific loss-of-function variants in the HSD17B13 gene are associated with protection against non-alcoholic fatty liver disease, steatohepatitis, and progression to cirrhosis. Conversely, altered expression of Hydroxysteroid 17 beta dehydrogenase 13 has been reported in fatty liver disease and hepatocellular carcinoma. Use of an HSD17B13 antibody enables analysis of protein expression patterns linked to liver pathology and disease susceptibility.

Hydroxysteroid 17 beta dehydrogenase 13 expression is largely restricted to liver tissue, with minimal expression detected in most extrahepatic tissues. This restricted distribution makes HSD17B13 a useful marker for hepatocyte identity and liver-specific metabolic states. An HSD17B13 antibody can therefore support studies of hepatic differentiation, liver injury, and metabolic remodeling.

Clone HSD17B13/13105 is designed to recognize Hydroxysteroid 17 beta dehydrogenase 13 and supports detection of HSD17B13 expression in research applications. NSJ Bioreagents offers this HSD17B13 antibody to support investigations into liver metabolism, fatty liver disease, and hepatocellular biology.

UniProt: Q7Z5P4