MUC16 anticorps (AA 1700-2000)

N° du produit ABIN8093336

L’anticorps anti-MUC16 Monoclonal Souris est utilisé pour la détection de MUC16 dans des échantillons de Humain. Il a été validé pour IHC.

Aperçu rapide pour MUC16 anticorps (AA 1700-2000) (ABIN8093336)

Antigène: MUC16 (CA125) (Mucin 16, Cell Surface Associated (CA125))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MUC16 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: CA125-8893

Détail du produit anti-MUC16 anticorps

Épitope: AA 1700-2000

Fonction: MUC16 Antibody / CA125

Immunogène: A recombinant fragment (around amino acids 1700-2000) of human MUC16 protein (exact sequence is proprietary) was used as the immunogen for the Cancer antigen 125 antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the Cancer antigen 125 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Cancer antigen 125 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Détails sur MUC16

Antigène: MUC16 (CA125) (Mucin 16, Cell Surface Associated (CA125))

Autre désignation: MUC16

Sujet: Cancer antigen 125 Antibody recognizes Mucin 16 (MUC16), a very high molecular weight transmembrane glycoprotein widely known as CA125 and Ovarian cancer antigen 125. MUC16 is a membrane-associated mucin characterized by extensive O-linked glycosylation, multiple tandem repeat domains, and a large extracellular region that can be proteolytically shed into circulation. Cancer antigen 125 Antibody is useful for detecting MUC16 expression in epithelial and tumor tissues in research applications.

MUC16 antibody, also referred to as CA125 antibody and Mucin-16 antibody in the literature, targets a mucin primarily expressed on the apical surface of epithelial cells lining the female reproductive tract, including endometrium and fallopian tube, as well as in ocular and respiratory epithelium. Under physiologic conditions, MUC16 contributes to epithelial barrier protection, lubrication, and defense against environmental stress. Release of its extracellular domain forms circulating CA125, which serves as a widely used serum biomarker for monitoring ovarian carcinoma.

The MUC16 gene is located on human chromosome 19p13.2 and encodes one of the largest membrane-associated proteins identified. Structurally, the protein contains numerous SEA domains, extensive tandem repeats, a transmembrane region, and a short cytoplasmic tail that participates in intracellular signaling interactions. MUC16 has been shown to bind mesothelin and contribute to tumor cell adhesion and peritoneal dissemination in ovarian cancer models.

Aberrant overexpression of MUC16 is most strongly associated with epithelial ovarian carcinoma and is also observed in subsets of endometrial, pancreatic, breast, lung, and gastrointestinal carcinomas. In histologic sections, MUC16 typically demonstrates apical membranous and cytoplasmic staining in positive epithelial tumor cells. A CA125 antibody is commonly applied in research settings to evaluate epithelial differentiation, tumor origin, and mucin biology. Clone CA125/8893 is a mouse monoclonal antibody developed to target MUC16 in experimental systems.

UniProt: Q8WXI7