PEX16 anticorps (N-Term)

N° du produit ABIN8093405

L’anticorps anti-PEX16 Polyclonal Lapin est utilisé pour la détection de PEX16 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, IF et IP.

Aperçu rapide pour PEX16 anticorps (N-Term) (ABIN8093405)

Antigène: PEX16 (Peroxisomal Biogenesis Factor 16 (PEX16))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PEX16 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Détail du produit anti-PEX16 anticorps

Épitope: N-Term

Fonction: PEX16 Antibody / Peroxisomal biogenesis factor 16

Purification: Immunogen affinity purified

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of human Peroxisomal biogenesis factor 16 was used as the immunogen for the PEX16 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the PEX16 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the PEX16 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur PEX16

Antigène: PEX16 (Peroxisomal Biogenesis Factor 16 (PEX16))

Autre désignation: PEX16

Sujet: PEX16 antibody targets Peroxisomal biogenesis factor 16, encoded by the PEX16 gene. Peroxisomal biogenesis factor 16 is a peroxisomal membrane protein that plays a key role in early stages of peroxisome membrane formation and maintenance. Unlike shuttling import receptors, PEX16 functions as a membrane-associated organizer that contributes to the establishment and stabilization of peroxisomal membranes.

Functionally, Peroxisomal biogenesis factor 16 participates in the recruitment and insertion of other peroxisomal membrane proteins, supporting the assembly of functional peroxisomes. It has been implicated in coordinating peroxisome membrane biogenesis from pre-existing peroxisomes or precursor membrane structures. A PEX16 antibody supports studies focused on peroxisome membrane formation, organelle biogenesis, and intracellular membrane trafficking.

PEX16 is predominantly localized to peroxisomal membranes, consistent with its role as a structural and organizational component rather than a transport receptor. Its membrane-associated distribution distinguishes it from matrix protein import receptors and reflects its involvement in shaping peroxisomal architecture. Through this role, Peroxisomal biogenesis factor 16 contributes indirectly to peroxisome-dependent metabolic processes, including lipid metabolism and reactive oxygen species regulation.

From a disease-related perspective, disruption of PEX16 function impairs peroxisome formation and has been linked to peroxisome biogenesis disorders. Loss of functional PEX16 compromises peroxisomal membrane integrity and downstream metabolic capacity, highlighting its importance in organelle development and cellular homeostasis. These findings make PEX16 a relevant target for studies of inherited metabolic disease and organelle dysfunction.

At the molecular level, Peroxisomal biogenesis factor 16 contains conserved membrane-associated regions that support its localization and interactions with other peroxins. Its apparent behavior in biochemical assays reflects its membrane-embedded nature rather than changes in protein structure or processing. PEX16 antibody reagents enable investigation of peroxisomal membrane biogenesis and organelle assembly, with NSJ Bioreagents providing reagents intended for research use.

UniProt: Q9Y5Y5