PVRL4 anticorps (AA 1-200)

N° du produit ABIN8093416

Cet anticorps Souris Monoclonal détecte spécifiquement PVRL4 dans WB et IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour PVRL4 anticorps (AA 1-200) (ABIN8093416)

Antigène: PVRL4 (Poliovirus Receptor-Related 4 (PVRL4))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PVRL4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: NECTIN4-9906

Détail du produit anti-PVRL4 anticorps

Épitope: AA 1-200

Fonction: NECTIN4 Antibody / Nectin cell adhesion molecule 4

Immunogène: A recombinant fragment (around amino acids 1-200) of human NECTIN4 protein (exact sequence is proprietary) was used as the immunogen for the Nectin cell adhesion molecule 4/NECTIN4 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the Nectin cell adhesion molecule 4/NECTIN4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Nectin cell adhesion molecule 4/NECTIN4 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Détails sur PVRL4

Antigène: PVRL4 (Poliovirus Receptor-Related 4 (PVRL4))

Autre désignation: NECTIN4

Sujet: Nectin cell adhesion molecule 4 antibody, also known as NECTIN4 antibody, recognizes Nectin cell adhesion molecule 4, a type I transmembrane glycoprotein encoded by the NECTIN4 gene. Commonly referred to as Nectin-4 and also known as Poliovirus receptor related 4 (PVRL4), this protein is a member of the nectin family within the immunoglobulin superfamily. NECTIN4 localizes primarily to the plasma membrane at adherens junctions, where it mediates Ca2+-independent cell-cell adhesion and contributes to epithelial tissue integrity. Nectin cell adhesion molecule 4 antibody is widely used in studies of epithelial organization, cell polarity, and tumor-associated membrane protein expression.

NECTIN4 contains three extracellular immunoglobulin-like domains, a single transmembrane region, and a cytoplasmic tail that interacts with intracellular adaptor proteins involved in junction assembly and cytoskeletal linkage. Through homophilic and heterophilic interactions with other nectin family members, Nectin cell adhesion molecule 4 regulates adhesion strength, cell sorting, and tissue morphogenesis. In normal tissues, expression is relatively restricted, with detectable levels in skin, placenta, and select epithelial compartments. During development, nectin family proteins play roles in coordinated cell positioning and junctional maturation.

Overexpression of NECTIN4 has been reported in several epithelial malignancies, including urothelial carcinoma, breast cancer, lung cancer, and ovarian cancer. Elevated membrane expression has been associated with enhanced proliferation and tumor progression, supporting its relevance as a biomarker in oncology research. Immunostaining typically demonstrates membranous localization in positive tumor cells, consistent with its function as a cell surface adhesion molecule. Clone NECTIN4/9906 is designed to detect Nectin cell adhesion molecule 4 in research applications and supports investigation of epithelial adhesion dynamics, tumor biology, and membrane-associated signaling pathways.

UniProt: Q96NY8

Pathways: Cell-Cell Junction Organization