Recombinant PVRL4 anticorps (Extracellular)

N° du produit ABIN8093418

Cet anticorps anti-PVRL4 Monoclonal Lapin (Clone NECTIN4-13438R) (ABIN8093418) détecte spécifiquement PVRL4 dans IHC et FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant PVRL4 anticorps (Extracellular) (ABIN8093418)

Antigène: PVRL4 (Poliovirus Receptor-Related 4 (PVRL4))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp PVRL4 est non-conjugé

Application: Immunohistochemistry (IHC), Flow Cytometry (FACS)

Clone: NECTIN4-13438R

Détail du produit anti-PVRL4 anticorps

Épitope: AA 266-280, Extracellular

Fonction: NECTIN4 Antibody / Poliovirus receptor related 4

Immunogène: A recombinant fragment (around amino acids 266-280) of human NECTIN4 protein corresponding to the extracellular domain (exact sequence is proprietary) was used as the immunogen for the Poliovirus receptor related 4/NECTIN4 antibody.

Isotype: IgG, kappa

Information d'application

Indications d'application: 1. Optimal dilution of the Poliovirus receptor related 4/NECTIN4 antibody should be determined by the researcher.

2. This Poliovirus receptor related 4/NECTIN4 antibody is recombinantly produced by expression in CHO cells.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Poliovirus receptor related 4/NECTIN4 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Détails sur PVRL4

Antigène: PVRL4 (Poliovirus Receptor-Related 4 (PVRL4))

Autre désignation: NECTIN4

Sujet: Poliovirus receptor related 4 antibody, also known as NECTIN4 antibody, recognizes Poliovirus receptor related 4, a type I transmembrane cell adhesion molecule encoded by the NECTIN4 gene. Commonly referred to as Nectin-4 and also designated PVRL4, this protein is a member of the nectin family within the immunoglobulin superfamily. NECTIN4 localizes predominantly to the cell membrane at adherens junctions, where it participates in Ca2+-independent cell-cell adhesion and contributes to maintenance of epithelial tissue architecture. Poliovirus receptor related 4 antibody is widely used in studies of epithelial biology and tumor-associated membrane protein expression.

NECTIN4 contains three extracellular immunoglobulin-like domains, a single transmembrane segment, and a cytoplasmic tail that interacts with intracellular adaptor proteins involved in junctional organization and cytoskeletal linkage. Through homophilic and heterophilic interactions with other nectin family members, Poliovirus receptor related 4 regulates cell polarity, adhesion strength, and tissue integrity. In normal tissues, expression is relatively restricted, with detectable levels in skin, placenta, and certain epithelial compartments. During development, nectin family proteins contribute to tissue morphogenesis and coordinated cell positioning.

Aberrant overexpression of Nectin-4 has been documented in multiple malignancies, including urothelial carcinoma, breast cancer, lung cancer, and ovarian cancer. Elevated NECTIN4 expression has been associated with enhanced proliferation and tumor progression, and the protein has been explored as a surface biomarker in oncology research. Immunostaining typically demonstrates membranous localization in positive tumor cells, consistent with its function as a cell surface adhesion molecule. Clone NECTIN4/13438R is a recombinant rabbit monoclonal antibody generated through defined sequence expression, supporting consistency between production lots. This Poliovirus receptor related 4 antibody enables investigation of NECTIN4 expression in research applications focused on epithelial adhesion, tumor biology, and membrane-associated signaling pathways.

UniProt: Q96NY8

Pathways: Cell-Cell Junction Organization