TFPI2 anticorps (AA 100-235)

N° du produit ABIN8093520

Cet anticorps anti-TFPI2 Monoclonal Souris (Clone TFPI2-13028) (ABIN8093520) détecte spécifiquement TFPI2 dans IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour TFPI2 anticorps (AA 100-235) (ABIN8093520)

Antigène: TFPI2 (Tissue Factor Pathway Inhibitor 2 (TFPI2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TFPI2 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: TFPI2-13028

Détail du produit anti-TFPI2 anticorps

Épitope: AA 100-235

Fonction: TFPI2 Antibody / Tissue factor pathway inhibitor 2

Immunogène: A recombinant fragment (around amino acids 100-235) of human TFPI2 protein (exact sequence is proprietary) was used as the immunogen for the Placental Protein 5/TFPI2 antibody.

Isotype: IgG2, kappa

Information d'application

Indications d'application: Optimal dilution of the Placental Protein 5/TFPI2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Placental Protein 5/TFPI2 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Détails sur TFPI2

Antigène: TFPI2 (Tissue Factor Pathway Inhibitor 2 (TFPI2))

Autre désignation: TFPI2

Sujet: Placental Protein 5 antibody, also known as TFPI2 antibody, recognizes Placental Protein 5, the historical name for Tissue factor pathway inhibitor 2 encoded by the TFPI2 gene. Originally identified in placental tissue, Placental Protein 5 is a secreted Kunitz-type serine protease inhibitor that associates with the extracellular matrix and regulates pericellular proteolysis. The protein contains three tandem Kunitz domains that enable inhibition of multiple serine proteases involved in matrix degradation and tissue remodeling. Placental Protein 5 antibody is widely used in research examining extracellular matrix regulation, trophoblastic biology, and tumor invasion mechanisms.

TFPI2 is synthesized with a signal peptide and secreted into the extracellular environment, where it binds matrix components and modulates local protease activity. Although structurally related to Tissue factor pathway inhibitor 1, Placental Protein 5 primarily functions in extracellular matrix homeostasis rather than directly regulating the tissue factor coagulation cascade. By inhibiting proteases such as plasmin and trypsin-like enzymes, TFPI2 contributes to maintaining tissue integrity and limiting excessive matrix breakdown. Reduced TFPI2 expression has been reported in various malignancies, often associated with promoter hypermethylation and increased invasive potential.

Expression of Placental Protein 5 has been documented in placenta, vascular endothelium, and selected epithelial tissues. In placental tissue, extracellular and pericellular localization patterns are consistent with its matrix-associated inhibitory role. In cancer biology studies, TFPI2 antibody is frequently used to evaluate epigenetic silencing, stromal interactions, and tumor microenvironment remodeling. Clone TFPI2/13028 is designed to detect Placental Protein 5 in research applications and supports investigation of extracellular protease regulation and matrix-associated signaling pathways.

UniProt: P48307