PLAG1 anticorps (Biotin)

N° du produit ABIN760528

Cet anticorps Lapin Polyclonal détecte spécifiquement PLAG1 dans WB et IHC (p). Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour PLAG1 anticorps (Biotin) (ABIN760528)

Antigène: PLAG1 (Pleiomorphic Adenoma Gene 1 (PLAG1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PLAG1 est conjugé à/à la Biotin

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-PLAG1 anticorps (Biotin)

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human PLAG1

Isotype: IgG

Information d'application

Indications d'application: WB 1:100-1000
IHC-P 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur PLAG1

Antigène: PLAG1 (Pleiomorphic Adenoma Gene 1 (PLAG1))

Autre désignation: Plag1

Sujet:

Synonyms: PSA, SGPA, ZNF912, Zinc finger protein PLAG1, Pleiomorphic adenoma gene 1 protein, PLAG1

Background: Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia.

ID gène: 5324

UniProt: Q6DJT9