BCL6 anticorps (AA 250-350)

N° du produit ABIN8119946

Cet anticorps Souris Monoclonal détecte spécifiquement BCL6 dans WB, IF et ELISA. Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour BCL6 anticorps (AA 250-350) (ABIN8119946)

Antigène: BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BCL6 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), ELISA

Clone: AB2431

Détail du produit anti-BCL6 anticorps

Épitope: AA 250-350

Fonction: Bcl-6 mouse mAb

Specificité: This antibody detects endogenous levels of Bcl-6.

Purification: The antibody was purified by protein G affinity chromatography.

Immunogène: A synthetic peptide corresponding to the amino acid region 250 - 350 of the human Bcl - 6 protein.

Isotype: IgG

Information d'application

Indications d'application: WB, 1:500-1:2000 | IF, 1:100-1:500 | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze / thaw cycles

Stock: -20 °C

Stockage commentaire: Store at-20°C. Avoid freeze / thaw cycles.

Détails sur BCL6

Antigène: BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

Autre désignation: Bcl-6

Sujet:

Synonyms: BCL6,BCL5,LAZ3,ZBTB27,ZNF51,B-cell lymphoma 6 protein,BCL-6,B-cell lymphoma 5 protein,BCL-5,Protein LAZ-3,Zinc finger and BTB domain-containing protein 27,Zinc finger protein 51

Background: The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL) , and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015],

Gene Name: BCL6 BCL5 LAZ3 ZBTB27 ZNF51

Protein Name: Bcl-6

ID gène: 604

UniProt: P41182

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus