Caspase-8 p18 anticorps (Cleaved-Ser217)

N° du produit ABIN8120241

L’anticorps anti-Caspase-8 p18 Polyclonal Lapin est utilisé pour la détection de Caspase-8 p18 dans des échantillons de Humain. Il a été validé pour WB et ELISA.

Aperçu rapide pour Caspase-8 p18 anticorps (Cleaved-Ser217) (ABIN8120241)

Antigène: Caspase-8 p18 (Caspase 8 Subunit P18)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Caspase-8 p18 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-Caspase-8 p18 anticorps

Épitope: AA 170-250, Cleaved-Ser217

Fonction: Cleaved-Caspase-8 p18 (S217) Antibody

Specificité: Cleaved-Caspase-8 p18 (S217) Polyclonal Antibody detects endogenous levels of Cleaved-Caspase-8 p18 (S217) protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from Cleaved-Caspase-8 p18 (S217) . at AA range: 170-250

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur Caspase-8 p18

Antigène: Caspase-8 p18 (Caspase 8 Subunit P18)

Autre désignation: Caspase-8 p18

Sujet:

Synonyms: CASP8, MCH5, Caspase-8, CASP-8, Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, FLICE, ICE-like apoptotic protease 5, MORT1-associated ced-3 homolog, MACH

Background: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alt

Gene Name: CASP8

Protein Name: Caspase8

ID gène: 841

UniProt: Q14790