CDT2/RAMP anticorps

N° du produit ABIN8120957

Cet anticorps Lapin Polyclonal détecte spécifiquement CDT2/RAMP dans WB et ELISA. Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour CDT2/RAMP anticorps (ABIN8120957)

Antigène: CDT2/RAMP (DTL) (Denticleless E3 Ubiquitin Protein Ligase Homolog (DTL))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDT2/RAMP est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-CDT2/RAMP anticorps

Fonction: DTL Antibody

Specificité: DTL Polyclonal Antibody detects endogenous levels of protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from part region of human protein

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-2000 ELISA 1:5000-20000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur CDT2/RAMP

Antigène: CDT2/RAMP (DTL) (Denticleless E3 Ubiquitin Protein Ligase Homolog (DTL))

Autre désignation: DTL

Sujet:

Background: developmental stage:Expressed in all fetal tissues examined, included brain, lung, liver, and kidney.,function:Required for CDT1 proteolysis in response to DNA damage through the CUL4-DDB1 E3 ubiquitin-protein ligase. Seems to be necessary to ensure proper cell cycle regulation of DNA replication. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. May play a role in cell proliferation of NT2 embryonal carcinoma cells.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the WD repeat cdt2 family.,similarity:Contains 7 WD repeats.,subcellular location:Nuclear matrix-associated protein. Translocates from the interphase nucleus to the metaphase cytoplasm during mitosis.,subunit:Probable part of a cullin-RING E3 protein ligase complex containing CUL4B-DDB1 and a substrate-recruiting component (DCAF). Interacts with CUL4B and DDB1.,tissue specificity:Expressed in placenta and testis, very low expression seen in skeletal muscle. Detected in all hematopoietic tissues examined, with highest expression in thymus and bone marrow. A low level detected in the spleen and lymph node, and barely detectable level in the peripheral leukocytes. RA treatment down-regulated the expression in NT2 cell.,

Gene Name: DTL CDT2 CDW1 DCAF2 L2DTL RAMP

Protein Name: Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein)

ID gène: 51514

UniProt: Q9NZJ0