DCLK1 anticorps (AA 514-564)

N° du produit ABIN8121064

Cet anticorps anti-DCLK1 Polyclonal Lapin (ABIN8121064) détecte spécifiquement DCLK1 dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour DCLK1 anticorps (AA 514-564) (ABIN8121064)

Antigène: DCLK1 (Doublecortin-Like Kinase 1 (DCLK1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DCLK1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-DCLK1 anticorps

Épitope: AA 514-564

Fonction: DCLK1 Antibody

Specificité: This antibody detects endogenous levels of DCLK1 at Human/Mouse/Rat

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from human DCLK1 AA range: 514-564

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur DCLK1

Antigène: DCLK1 (Doublecortin-Like Kinase 1 (DCLK1))

Autre désignation: DCLK1

Sujet:

Background: This gene encodes a member of the protein kinase superfamily and the doublecortin family.The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010],

Gene Name: DCLK1 DCAMKL1 DCDC3A KIAA0369

Protein Name: DCLK1

ID gène: 9201

UniProt: O15075