Glutathione Peroxidase 2 anticorps (AA 113-163)

N° du produit ABIN8121709

Cet anticorps anti-Glutathione Peroxidase 2 Polyclonal Lapin (ABIN8121709) détecte spécifiquement Glutathione Peroxidase 2 dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Glutathione Peroxidase 2 anticorps (AA 113-163) (ABIN8121709)

Antigène: Glutathione Peroxidase 2 (GPX2)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Glutathione Peroxidase 2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Glutathione Peroxidase 2 anticorps

Épitope: AA 113-163

Fonction: GPX2 Antibody

Specificité: This antibody detects endogenous levels of GPX2 at Human/Mouse/Rat

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from human GPX2 AA range: 113-163

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur Glutathione Peroxidase 2

Antigène: Glutathione Peroxidase 2 (GPX2)

Autre désignation: GPX2

Sujet:

Background: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract (also in liver in human), is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Overexpression of this gene is associated with increased differentiation and proliferation in colorectal cancer. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016],

Gene Name: GPX2

Protein Name: GPX2

ID gène: 2877

UniProt: P18283

Pathways: Thyroid Hormone Synthesis