HJURP anticorps (AA 80-160)

N° du produit ABIN8122100

Cet anticorps Lapin Polyclonal détecte spécifiquement HJURP dans WB et ELISA. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour HJURP anticorps (AA 80-160) (ABIN8122100)

Antigène: HJURP (Holliday Junction Recognition Protein (HJURP))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HJURP est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-HJURP anticorps

Épitope: AA 80-160

Fonction: HJURP Antibody

Specificité: HJURP Polyclonal Antibody detects endogenous levels of protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from human protein . at AA range: 80-160

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-2000 ELISA 1:5000-20000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur HJURP

Antigène: HJURP (Holliday Junction Recognition Protein (HJURP))

Autre désignation: HJURP

Sujet:

Background: function:Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Directly binds Holliday junctions.,sequence caution:Translated as Arg.,subcellular location:Localizes in centromeres during late telophase and early G1, when CENPA nucleosomes are assembled. Localizes to nucleolus during S phase, nucleolus site being often related to storage.,subunit:Interacts with CENPA (via CATD domain), the interaction is direct and specific for CENPA since it does not interact with H3.1- or H3.3-containing nucleosomes. Interacts with 14-3-3 family members in a phosphorylation-dependent manner. Interacts with MSH5 and NBN.,tissue specificity:According to PubMed:17256767 highly expressed in the thymus with lower levels in the placenta, small intestine, liver, skeletal muscle, and colon. According to PubMed:17823411 highly expressed in testis, and at a relatively lower level in thymus and bone marrow. Significantly overexpressed in many lung cancer samples, compared with normal lung.,

Gene Name: HJURP FAKTS FLEG1 URLC9

Protein Name: Holliday junction recognition protein (14-3-3-associated AKT substrate) (Fetal liver-expressing gene 1 protein) (Up-regulated in lung cancer 9)

ID gène: 55355

UniProt: Q8NCD3