Huntingtin anticorps (acLys442)

N° du produit ABIN8122113

L’anticorps anti-Huntingtin Polyclonal Lapin est utilisé pour la détection de Huntingtin dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB et ELISA.

Aperçu rapide pour Huntingtin anticorps (acLys442) (ABIN8122113)

Antigène: Huntingtin (HTT)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Huntingtin est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-Huntingtin anticorps

Épitope: acLys442

Fonction: Huntingtin (Acetyl Lys442) Antibody

Specificité: This antibody detects endogenous levels of Human,Mouse,Rat Huntingtin (Acetyl Lys442)

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogène: Synthesized peptide derived from human Huntingtin (Acetyl Lys442)

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-2000 ELISA 1:5000-20000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur Huntingtin

Antigène: Huntingtin (HTT)

Autre désignation: Huntingtin

Sujet:

Synonyms: Huntingtin (Huntington disease protein; HD protein)

Background: huntingtin(HTT) Homo sapiens Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range of trinucleotide repeats (9-35) has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widel

Gene Name: HTT HD IT15

Protein Name: Huntingtin (Acetyl Lys442)

ID gène: 3064

UniProt: P42858

Pathways: Signalisation PI3K-Akt, Hormone Transport, Transition Metal Ion Homeostasis, Tube Formation, Protein targeting to Nucleus, Dicarboxylic Acid Transport