Importin 9 anticorps

N° du produit ABIN8122170

L’anticorps anti-Importin 9 Polyclonal Lapin est utilisé pour la détection de Importin 9 dans des échantillons de Humain et Souris. Il a été validé pour WB et ELISA.

Aperçu rapide pour Importin 9 anticorps (ABIN8122170)

Antigène: Importin 9 (IPO9)

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Importin 9 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-Importin 9 anticorps

Fonction: IPO9 Antibody

Specificité: IPO9 Polyclonal Antibody detects endogenous levels of protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from part region of human protein

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-2000 ELISA 1:5000-20000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur Importin 9

Antigène: Importin 9 (IPO9)

Autre désignation: IPO9

Sujet:

Background: function:Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of H2B histone (By similarity), RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. May also import H2A, H3, H4 histones (By similarity), RPL4 and RPL6.,similarity:Belongs to the importin beta family.,similarity:Contains 1 importin N-terminal domain.,subunit:Binds with high affinity to RPS7 and RPL18A. The binding is coupled to RanGTP cycles. May bind H2A, H3, H4 histones (By similarity), RPL4 and RPL6 with low affinity. Interacts with PPP2R1A and PPP2R1B.,

Gene Name: IPO9 IMP9 KIAA1192 RANBP9 HSPC273

Protein Name: Importin-9 (Imp9) (Ran-binding protein 9) (RanBP9)

ID gène: 55705

UniProt: Q96P70

Pathways: Protein targeting to Nucleus